Can the Latest human research of resveratrol widen its future Application?

Recently, in a random double-blind, placebo-controlled clinical trial published in the journal Applied Psychology, Nutrition and Metabolism, the researchers evaluated the effect of resveratrol supplements with appropriate exercise on human skeletal muscle mitochondria, while also found that piperine can improve the bioavailability of a range of nutrients.
In this trial, the researchers recruited 16 healthy young adult volunteers. The volunteers took 4 weeks of resveratrol and piperine continuously, at a dose of 1000 mg and 20 mg, respectively. The results showed that compared with the control group, the muscle oxidative ability of volunteers returned to normal in a short time after exercise. Therefore, Researchers believed that the impact of resveratrol on low-intensity stimulation in endurance training is one of the most striking findings in recent years. The result of this study is of great significance to the public, especially to those who are unable to perform high-intensity exercise.

The magic of resveratrol
In fact, the story about resveratrol dates back to the 1980s, the so-called “French Paradox”: Although the French diet has a high fat content, the incidence of cardiovascular disease in France is not high. Some researchers attribute it to romantic French people love drinking red wine, while red wine contains resveratrol which can prevent cardiovascular disease. This also provides a “scientific” reason for the drunks to drink wine again and again.
However, in the scientific field, resveratrol still retains its magic. Scientists have actively researched into the resveratrol naturally existing in more than 70 plants, including pine bark, peanuts, cocoa, blueberries and raspberries. Of course, there is no interruption in the study of wine.

Indeed, any ingredient that is as widely used as resveratrol is likely to fluctuate in the nutrition market over time. However, the benefits of resveratrol in anti-aging, women's health, cardiovascular, skin, bone, and especially cognitive health have been confirmed. Scientific research on resveratrol continues to yield satisfactory results, and the health industry is re-recognizing its benefits.
Nevertheless, many people mistakenly believe that as long as they drink red wine, there is no need to take resveratrol supplements. Most of them are alcoholics. Moreover, those who hold this idea must also have an extraordinary amount of alcohol, because drinking 41 glasses of red wine can only get 20 mg of resveratrol.
New research on resveratrol
Shaheen Majeed, the Chairman of Sabinsha said that science itself is also partly responsible for the situation of resveratrol supplements. Most of the previous research results are based on cell culture or animal experiments, and only a few human clinical studies have demonstrated the long-term intake of resveratrol. The good news, however, is that recent research "trying to fill these gaps with well-designed human research.". Perhaps resveratrol is ready to bounce back.
It is reported that DSM conducted a rapid PubMed search on December 13, 2017. The total number of clinical trials and publications on resveratrol has exceeded 120, and this data is increasing every year.
Majeed added that clinical trials of resveratrol are increasingly targeting a variety of challenging indications, including respiratory infections, obesity, osteoarthritis, hepatitis, type 2 diabetes, cancer and cardiovascular disease. But for many resveratrol researchers, its real potential lies in its relationship with human health, which some call "the most relevant areas of activity." Because as the population ages, the demand for safe eating interventions has never been higher, in order to maintain optimal cognitive function.
However, Majeed also admitted that the anti-aging effect of resveratrol is "not very clear." Some people think that cognitive health is a "liquidity" form, and resveratrol can effectively improve many of the key neurological functions in the elders, mainly through its effects on mitochondria. Human cognitive function will pass with age, and resveratrol has been proved to be "capable of penetrating cells, helping mitochondria rejuvenate and achieve healthy aging."
Other studies have shown that in certain types of yeast, aphids, fruit flies and human cells, resveratrol appears to activate the gene of sirtuins, an ancient protein found in almost all species. Genes that control the environment may give organisms a survival advantage, especially when stress is high. Activation of sirtuins is thought to cause disease and prolong life reactions. However, a lot of research is still needed to better understand its mechanism of action.
This is an exciting discovery which reveals a part of the mechanism of action of this molecule to prolong people's life, which is believed to regulate genes associated with longevity. This finding will provide new possibilities for understanding the human aging process.
Resveratrol and cognitive health

According to the survey data, among the elderly over 65 years old, the probability of women suffering from cognitive syndrome is 14%, and that of men is 32%. By the age of 80, 63% of women suffer from cognitive syndrome. The worse matter is that the trend is likely to increase as the population ages. Scientists are actively exploring how to reverse this trend. Actually, a recent study reported that menopausal women who took resveratrol supplements had better language, memory and overall cognitive ability than menopausal women who took placebo.
For example, in a randomized, placebo-controlled trial, the researchers recruited 80 menopausal women volunteers between the ages ranging from 45 to 85. The volunteers were randomized into two groups, one taking 75 mg of trans-resveratrol and the other taking a placebo twice a day. The test lasted for 14 weeks. The study then evaluated the subject's cognitive ability, cerebral blood flow velocity, midbrain artery index (an indicator of arteriosclerosis), cognitive tests, and cerebral vascular response capacity (CVR) of hypercapnia (carbon dioxide retention). . 
Besides, the researchers assessed the mood of volunteers through an emotional questionnaire survey.The study showed that resveratrol helped CVR increase by 17% relative to placebo, while significantly improving language, memory tasks, and overall cognitive ability. Unfortunately, although resveratrol also improved the mood of volunteers, these changes were not significant.
In addition to demonstrating that resveratrol enhances cerebrovascular function and cognitive function in menopausal women, the results also suggest that some of the observed effects on cerebral blood flow may be important in the clinic, especially for the elderly.
Resveratrol and joint health
The researchers also evaluated the effects of resveratrol on the health of women's joints over the years, especially age-related osteoarthritis, such as joint problems caused by decreased vascular dysfunction and estrogen secretion.
In this trial, 80 healthy menopausal women were divided into two groups, one taking 75 mg of resveratrol per day and one taking a placebo for 14 days. Before and after the trial, the researchers measured health indicators for volunteers including pain, menopausal symptoms, sleep quality, depressive symptoms, mood, and quality of life. In addition, the researchers also tested the response of cerebral vasodilation to hypercapnia, a biomarker of cerebrovascular function.
The researchers found that resveratrol supplements significantly reduced pain and improved overall health of the subject compared with placebo, both of which are indicators of improved quality of life and are associated with improved cerebral vascular function. The researchers said that although more research is needed, existing studies have shown that resveratrol can reduce chronic pain associated with age-related osteoarthritis and may enhance happiness of postmenopausal women.
According to the researchers, they are conducting a larger follow-up study in which they plan to assess the effects of resveratrol on cerebrovascular function, cognitive performance and bone health, involving 160 menopausal women. The test results will be announced in the middle of 2019.