Urolithin A

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[ Synonyms ] Uro-A
[ Cas No. ] 1143-70-0
[ Molecular Formula ] C13H8O4
[ Formula Weight ] 228.203
[ Assay ] ≥98%
[ Appearance ] Light Yellow Powder

[ Function ]
1. Inhibits the proliferation of dysfunctional, aging mitochondria, thereby extending mitochondrial lifespan;
2. Extends mitochondrial lifespan and induces cellular mitosis, exerting a reversing effect on the aging of hematopoietic stem cells and the immune system;
3. Acts as an anti-inflammatory and antioxidant agent, inhibiting the expression of inflammatory mediators and reducing oxidative damage;
4. Alleviates muscle loss and enhances the endurance of skeletal muscles;
5. Helps boost muscle contractile strength, playing a particularly positive role in maintaining or improving muscle function;
6. Mitigates oxidative stress by simultaneously scavenging free radicals and inhibiting oxidase enzymes;
7. Helps alleviate sleep-related issues, such as difficulty falling asleep and nocturnal awakenings;
8. Reduces wrinkles, improves skin hydration, and inhibits collagen degradation;
9. Influences cellular lipid metabolism and adipogenesis, thereby aiding in weight loss;

About Urolithin A
Urolithin A  is a natural compound produced by your gut bacteria when you eat foods like pomegranates, berries, and nuts . It is primarily known for its ability to recycle damaged mitochondria through a process called mitophagy, which tends to decline with age.
The primary efficacy of Urolithin A lies in activating cellular mitochondrial renewal mechanisms, enhancing muscle function, and mitigating inflammatory responses; notably, its effects are influenced by individual variations in gut microbiota. As a gut metabolite, Urolithin A induces mitophagy, improves musculoskeletal health, and exhibits anti-inflammatory and anti-cancer properties.
Urolithin A triggers cells to initiate the process of "mitophagy"—the selective degradation of mitochondria—thereby identifying and eliminating old, dysfunctional, or damaged mitochondria. While clearing away aging mitochondria, it simultaneously stimulates the generation of new, more functionally efficient mitochondria. By renewing the mitochondrial population, it enhances the efficiency with which cells utilize oxygen to generate energy, thereby providing more abundant energy support for various bodily functions. This capacity to promote mitochondrial renewal may help delay age-related functional decline.
The core action of Urolithin A is intimately linked to mitophagy. It activates the cellular machinery responsible for clearing out aging or damaged mitochondria, thereby maintaining the efficiency of cellular energy metabolism. Furthermore, it attenuates inflammatory responses by inhibiting the NF-κB signaling pathway and boosts the activity of antioxidant enzymes, thereby minimizing cellular damage caused by free radicals.
Clinical trials have demonstrated that Urolithin A supplementation can enhance muscle endurance in middle-aged and older adults and reduce post-exercise lactic acid accumulation—effects that are likely attributable to the optimization of mitochondrial function.