Trilobatin

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[ Herb Source ] Lithocarpus litseifolius
[ CAS NO. ] 4192-90-9
[ Molecular Formula ] C21H24O10
[ Molecular Weight ] 436.4
[ Appearance ] Pale Yellow Crystalline Powder
[ Purity ] ≥95%

[ Function ]
1. Protects the cardiovascular system by lowering blood lipids and inhibiting vascular endothelial damage;
2. Improves insulin resistance and helps control blood glucose levels;
3. Inhibits the release of pro-inflammatory factors (such as TNF-α and IL-6), thereby alleviating chronic inflammatory responses;
4. Scavenges free radicals and reduces oxidative stress-induced cellular damage;
5. Significantly inhibits pancreatic α-amylase and α-glucosidase, and improves insulin resistance;
6. Exhibits free radical scavenging activity and provides cellular protection;
7. Significantly inhibits inflammatory responses;
8. Inhibits drug-resistant lung cancer cells and the HIV virus;

[ Application ]
1. Food Additive
As a natural sweetener, trilobatin is more than 300 times sweeter than sucrose and can be used as a sweetener in products such as foods, beverages, chewing gum, and tablets.
The recommended dosage is 0.2–0.8 grams per kilogram of food.
2. Pharmaceutical Raw Material
Trilobatin exhibits significant biological activity and can serve as a raw material for pharmaceuticals with antioxidant, anti-inflammatory, lipid-lowering, and blood glucose-lowering properties.
The recommended dosage is 50–100 milligrams per day.

About Trilobatin
Trilobatin is a natural sweetener extracted from plants such as lithocarpus polystachyus (sweet tea). It is more than 300 times sweeter than sucrose and possesses good stability; it can serve as a sucrose substitute, imparting a unique flavor to the resulting products. Additionally, it exhibits various biological activities and is widely used in scientific and pharmaceutical research.
Research indicates that trilobatin inhibits the activity of α-glucosidase and α-amylase, helping to delay the digestion and absorption of carbohydrates; consequently, it shows potential for assisting in blood sugar stabilization.
Trilobatin possesses antioxidant activity, helping to scavenge free radicals in the body and reduce oxidative damage.
As a functional natural sweetener, trilobatin offers a clean sweet taste, is non-cariogenic, does not raise blood sugar levels, and exhibits specific biological activities. With effects including blood sugar reduction, antioxidant, anti-inflammatory, and anti-tumor properties, as well as a pleasant taste profile, trilobatin shows promise as the next major natural high-intensity sweetener, following in the footsteps of steviol glycosides and mogrosides.