[ CAS NO. ] 284461-73-0
[ Molecular Formula ] C21H16ClF3N4O3
[ Molecular Weight ] 464.83
[ Density ] 1.454 g/cm3
[ Melting Point ] 225-235ºC
[ Boiling Point ] 523.3ºC at 760 mmHg
[ Flash Point ] 270.3ºC
[ Vapor Pressure ] 4.76E-11mmHg at 25°C
[ Appearance ] White powder
Sorafenib is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer.
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