Sophoricoside

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[ Source ] Styphnolobium japonicum (L.) Schott
[ CAS No. ] 152-95-4
[ Molecular Formula ] C21H20O10
[ Molecular Weight ] 432.381
[ Appearance ] Pale Yellow Powder
[ Purity ] ≥98%

[ Function ]
1. Anti-inflammatory and anti-allergic effects:
Inhibits the release of histamine and the expression of pro-inflammatory factors (TNF-α, IL-6, IL-8), thereby alleviating symptoms of atopic dermatitis and allergic asthma.
2. Anti-cancer effects:
Exerts an inhibitory effect on hepatocellular carcinoma (HCC) cells; it can be used alone or in combination with lenvatinib (targeting EGFR) to treat HCC, and it suppresses cancer progression by activating the AMPK pathway.
3. Immunosuppression:
Inhibits the differentiation of CD4+ T cells into Th1, Th2, and Th17 subsets, leading to a reduction in immune responses.
4. Amelioration of osteoporosis:
Activates the Wnt/β-catenin signaling pathway and upregulates markers of bone metabolism.
5. Anti-cardiac hypertrophy:
Mitigates cardiac hypertrophy by promoting autophagy via the AMPK/mTORC1 pathway.
6. Regulation of lipid metabolism:
Inhibits lipid accumulation in HepG2 cells and downregulates genes associated with the SREBP pathway.

About SophoricosideSophoricoside is a naturally occurring isoflavone glycoside primarily isolated from the fruits and seeds of Sophora japonica L., also known as Styphnolobium japonicum.
It is a bioactive flavonoid compound belonging to the isoflavone family. Sophoricoside has attracted scientific interest because of its potential anti-inflammatory, antioxidant, skin-protective, and hair-growth-promoting properties.
As a naturally occurring isoflavone, Sophoricoside is of interest in research involving oxidative stress and cellular protection.
Sophoricoside has demonstrated anti-inflammatory activity in experimental research. It may help regulate inflammatory immune responses and reduce the production of pro-inflammatory cytokines.
Sophoricoside has shown potential in skin-protection research, particularly in experimental models of atopic dermatitis.
It is particularly interesting for cosmetic, pharmaceutical, and functional ingredient research.