SLU-PP-915

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[ CAS NO. ] ‌2285432-92-8
[ Molecular Formula ] C17H13BFNO3S
[ Molecular Weight ] 341.16
[ Appearance ] White Powder
[ Purity ] 98%HPLC

[ Function ]
1. Heart Failure Treatment:
Improves cardiac contractile function and increases survival rates by enhancing cardiac fatty acid metabolism and mitochondrial function.
2. Metabolic Diseases:
Shows promise for treating obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis (MASH).
3. Muscle Disorders:
Can mimic the effects of aerobic exercise and increase oxidative skeletal muscle fibers, offering potential therapeutic benefits for sarcopenia and muscular dystrophy.

About SLU-PP-915
SLU-PP-915 is a pan-ERR agonist that activates ERRα, ERRβ, and ERRγ. It enhances ERR-mediated transcriptional activity and promotes the expression of genes associated with mitochondrial function and oxidative metabolism; it is used to study energy metabolism-related disorders such as heart failure and metabolic syndrome, primarily to enhance cardiometabolic function and exercise endurance.
SLU-PP-915 simultaneously activates all three isoforms of the estrogen-related receptor (ERRα, ERRβ, and ERRγ).
SLU-PP-915 significantly upregulates the expression of genes related to energy metabolism, such as PGC-1α and lactate dehydrogenase A.