Seglitide

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[ Other Name ] Seglitide; MK-678
[ CAS No. ] 81377-02-8
[ Molecular Formula ] C44H56N8O7
[ Molecular Weight ] 808.98
[ Appearance ] White Powder
[ Purity ] ≥98%

[ Function ]
1. Inhibits glucagon secretion and lowers circulating insulin levels;
2. Following receptor activation, it inhibits adenylyl cyclase and reduces cAMP production, thereby suppressing the release of hormones such as growth hormone, insulin, and glucagon, while also regulating the secretion of neurotransmitters;
3. Exerts a blood pressure-lowering effect and inhibits plasma levels of glucagon and growth hormone;

[ Application ]
Primarily used in research on hypertension complicated by insulin-dependent diabetes mellitus.

About Seglitide (MK-678)
Seglitide is a glucagon-like peptide-1 (GLP-1) receptor agonist. It binds specifically to the GLP-1 receptor, activating a series of intracellular signaling pathways that promote insulin secretion and inhibit glucagon secretion, thereby lowering blood glucose levels. Additionally, it slows gastric emptying and reduces appetite, which helps with weight control. Furthermore, long-term use may offer protective and restorative effects on pancreatic beta cells and help improve insulin resistance.
Seglitide also exhibits blood pressure-lowering effects and can suppress plasma glucagon and growth hormone levels. Seglitide may be used in diabetes research.