Recombinant Human Epidermal Growth Factor (rhEGF)

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[ Other Name ] Recombinant human epidermal growth factor; rhEGF; Nepidermin
[ CAS NO. ] 62253-63-8
[ Molecular Formula ] C270H401N73O83S7
[ Molecular Weight ] 6222.03
[ Appearance ] White Powder
[ Purity ] ≥98% (by SDS-PAGE)
[ Endotoxin ] < 0.1 ng/μg of EGF
[ Biological Activity ] ED50 ≤2 ng/ml (determined by dose-dependent stimulation of thymidine uptake by BALB/c 3T3)
[ Specific Activity ] ≥5 × 105 units/mg

[ Function ]
1. Burn and Scald Wounds:
Suitable for treating superficial to deep partial-thickness (second-degree) burns and scalds, residual wounds, and donor sites; helps alleviate pain and accelerates the process of eschar separation.
2. Chronic Ulcers:
Includes hard-to-heal wounds such as diabetic foot ulcers, pressure ulcers, and vascular or radiation-induced ulcers; improves local microcirculation and promotes the regeneration of healthy tissue.
3. Various Traumatic Wounds:
Covers fresh and hard-to-heal skin wounds—such as surgical incisions, abrasions, and cuts—helping to shorten healing time and improve the quality of healing.
4. Ocular Injuries:
Specifically designed for the repair of ocular wounds, including corneal abrasions, post-operative corneal conditions, and corneal epithelial damage associated with dry eye syndrome.

About Recombinant Human Epidermal Growth Factor (rhEGF)
Recombinant human epidermal growth factor (rhEGF) is a topical biological agent that promotes the repair of skin and mucosal wounds. According to the U.S. National Cancer Institute (NCI), it accelerates wound healing by stimulating the proliferation, differentiation, and migration of epithelial cells. Common dosage forms include gels, eye drops, and topical solutions (sprays), and it is primarily used for the repair and treatment of burns, chronic ulcers, surgical wounds, and corneal injuries.
Recombinant human epidermal growth factor (rhEGF) is widely used in clinical practice to promote the repair and healing of various wounds—including corneal injuries, burns and scalds, surgical incisions, diabetic foot ulcers, skin graft donor sites, pressure ulcers, and skin ulcers—thereby helping to shorten healing time and improve healing quality. Notably, while recombinant human epidermal growth factor (rhEGF) gel can be applied to the entire face for a short period to treat extensive, severe damage to the facial stratum corneum, it is not intended for long-term, full-face use as a daily skincare product. In China, rhEGF eye drops and gel have been approved for marketing as Class I new drugs. Additionally, rhEGF is used as an additive in cell culture and is incorporated into certain anti-aging skincare products.