Pyrroloquinoline Quinone (PQQ)

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[ Synonyms ] 4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ
[ Cas No. ] 72909-34-3
[ Molecular Formula ] C14H6N2O8
[ Formula Weight ] 330.21
[ Assay ] ≥95.0% (HPLC)
[ Stability ] Light and Temperature Sensitive
[ Appearance ] Reddish-brown Powder

[ Function ]
1. Comprehensively improve human immune function;
2. Reduce serum bilirubin and alanine aminotransferase levels, maintains normal liver function, ameliorates liver injury, and demonstrates excellent therapeutic efficacy against liver diseases;
3. Can effectively eliminate free radicals within the body, thereby reducing the harm they cause to the human body;
4. Promote the synthesis of neurotrophic factors and help regulate various nervous system disorders;
5. Stimulate biological growth, capable of stimulating human cell growth and increasing cell density;
6. Can effectively prevent and treat Alzheimer's disease, improve memory, and effectively enhance cognitive function;
7. Block transferrin receptors on tumor cells, thereby inhibiting their function, tumor growth, and metastasis;
8. Protect the heart from oxidative damage;

[ Application ]
1. Pharmaceutical:
PQQ is considered potential candidates for the development of novel antioxidants, antimicrobial agents, and anti-tumor drugs.
2. Food and Health Supplements:
Due to their antioxidant properties, PQQ may be added to food products and health supplements to extend shelf life or enhance nutritional value.
3. Plant Science:
PQQ can increase microbial populations in the soil and boost levels of available phosphorus and chlorophyll in plants, thereby promoting plant growth.

About Pyrroloquinoline Quinone (PQQ)
Pyrroloquinoline Quinone (PQQ) is a naturally occurring redox cofactor of microbial quinoprotein enzyme, and imidazopyrroline,that acts as an essential nutrient, antioxidant, and has exert potent immunosuppressive effects.It is present in nanomolar quantities in most foods and in most animal tissuse.It is a potent antioxidant that scavenges superoxide and peroxinitrite.It is neuroprotectant against 6-hydroxydopamine-induced and hypoxia/ischemia-induced neurotoxicity.
In anti-aging dietary supplements, pyrroloquinoline quinone (PQQ) frequently serves as a key ingredient in multi-component formulations. PQQ targets mitochondrial function and promotes mitochondrial biogenesis. It boosts cellular energy in a gentle and sustained manner.
In the food sector, the United States, the European Union, and Canada have approved its use in food and beverages. The EU has authorized pyrroloquinoline quinone disodium salt as a novel food ingredient; however, given the lack of sufficient safety data regarding its consumption by infants, young children, pregnant women, and breastfeeding women, product labeling for relevant items must clearly indicate that it is unsuitable for these specific populations. In the field of animal production, PQQ has been shown to enhance growth and reproductive performance in mammals, as well as to regulate lipid metabolism in poultry. PQQ is also utilized in the dietary supplement industry. In the pharmaceutical sector, PQQ has garnered significant attention in research concerning the prevention and treatment of various conditions, including neurodegenerative diseases, physiological injuries, and obesity-related syndromes.