PP405

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[ CAS No. ] 2260696-63-5
[ Molecular Formula ] C20H11F6N3O2
[ Purity ] 99%
[ Appearance ] White Powder

[ Function ]
1. Slows Hair Loss;
2. Stimulates Hair Growth;

About PP405
PP405 is a mitochondrial pyruvate carrier inhibitor. It treats male-pattern hair loss by inhibiting the MPC and reprogramming the metabolism of hair follicle stem cells. By inhibiting the mitochondrial pyruvate carrier (MPC), PP405 blocks the entry of pyruvate into the mitochondria, thereby compelling hair follicle stem cells to shift from oxidative phosphorylation to glycolytic metabolism and, consequently, elevating intracellular lactate levels.
The core function of PP405 lies in its ability—through the precise stimulation of intracellular Myc levels or the inhibition of Mpc1 carrier activity—to effectively boost lactate production within hair follicle stem cells, thereby locally restarting and driving the hair growth cycle.