Piperlongumine

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[ Other Name ] Piperlongumine; Piplartine; Piperlongumin
[ CAS NO. ] 20069-09-4
[ Molecular Formula ] C17H19NO5
[ Molecular Weight ] 317.341
[ Appearance ] Off-white to light yellow solid
[ Purity (HPLC) ] ≥98.0%

[ Function ]
1. By increasing reactive oxygen species (ROS) levels within tumor cells, it induces apoptosis in cancer cells and inhibits the proliferation of gastric cancer, lung cancer, etc.;
2. It regulates the expression of multidrug resistance genes, enhancing sensitivity to chemotherapy drugs;
3. It inhibits NLRP3 inflammasome activation, alleviating inflammatory responses such as gout and arthritis;
4. It lowers blood lipids and platelet aggregation, and inhibits myocardial fibrosis;

About Piperlongumine
Piperlongumine is primarily extracted from plants of the Piperaceae family, such as Piper longum, and possesses various biological activities, including anti-inflammatory, antioxidant, and antitumor effects. Piperlongumine has wide applications in the pharmaceutical, health supplement, and research fields.
Piperlongumine has anti-myocardial fibrosis effects, inhibiting the transformation of myofibroblasts by suppressing the ERK1/2 signaling pathway. It is also a thromboxane A(2) receptor antagonist and can inhibit platelet aggregation.