Paromomycin

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[ CAS No. ] 7542-37-2
[ Molecular Formula ] C23H45N5O14
[ Molecular Weight ] 615.634
[ Assay ] 92% min
[ Appearance ] White Powder

[ Mechanism of Action ]
1. Inhibits bacterial/protozoan protein synthesis by binding to the 30S ribosomal subunit;
2. May disrupt mitochondrial membrane potential, inducing protozoan apoptosis-like death;

[ Main Indication ]
1. Bacterial Dysentery: Effective against diarrhea caused by Shigella and other enteropathogenic bacteria.
2. Amoebic Dysentery: Directly targets Entamoeba histolytica trophozoites, relieving intestinal symptoms.
3. Preoperative Bowel Preparation: Used for preoperative bowel cleansing to reduce the risk of postoperative infection.

About Paromomycin
Paromomycin is a sulfate form of aminoglycoside broad-spectrum antibiotic primarily used to treat intestinal protozoan infections and certain bacterial intestinal diseases. Its antibacterial spectrum is similar to neomycin and kanamycin, inhibiting both Gram-positive and Gram-negative bacteria, and also exhibiting killing effects against amoebae, cryptosporidia, and tapeworms.
Paromomycin kills bacteria by binding to their ribosomes, inhibiting protein synthesis. Simultaneously, it directly kills amoebae trophozoites and indirectly reduces the parasite's survival environment by inhibiting the intestinal symbiotic flora.