O-304

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[ CAS NO. ] 1261289-04-6
[ Molecular Formula ] C16H11Cl2N3O2S
[ Molecular Weight ] 380.2
[ Appearance ] White Powder
[ Purity ] ≥98%

[ Feature ]
1. High purity: O-304 is produced through a refined manufacturing process, achieving high product purity. High purity means better bioavailability.
2. Biological Activity: O-304 enhances AMPK activity by inhibiting the dephosphorylation of PAMPK.

[ Application ]
1. AMPK Activation: 
O-304 increases AMPK activity by inhibiting the dephosphorylation process of phosphorylated AMPK (pAMPK), thereby regulating energy metabolism balance.
2.Improving glucose metabolism:
In animal studies, a dose of 100 mg/kg of O-304effectively helped maintain stable fasting blood glucose and plasma insulin levels, sig nificantly reducing the metabolic burden caused by a high-fat diet, and preventing bl ood glucose fluctuations and abnormal insulin elevation triggered by dietary imbalan ces.
3. Protecting vascular elasticity: 
O-304 helps maintain blood pressure at healthy levels, reduces stress on blood vessels, and provides long-term, gentle protection for the cardiovascular and cerebrovascular systems, supporting emotional stability and sustained energy.
4.Promoting lasting youthfulness: 
O-304 precisely targets the AMPK-mTOR signaling pathway, intelligently regulating the process of cellular autophagy, promoting the catabolism of aged proteins and abnormal lipids, and maintaining a clean and vibrant cellular environment, thereby delaying cellular aging.

About O-304
O-304 is a small-molecule AMPK activator that enhances AMPK activity by inhibiting the dephosphorylation of phosphorylated AMPK (pAMPK), thereby increasing pAMPK levels without reducing intracellular adenosine triphosphate (ATP) concentrations. It possesses multiple mechanisms of action, including improving glucose metabolism, reducing insulin resistance, and protecting the cardiovascular system.
O-304 is a small molecule compound that targets AMPK (adenosine monophosphate-activated protein kinase). By activating intracellular energy metabolic pathways, it mimics the physiological effects of exercise, such as improving insulin resistance and enhancing cardiac function. Its core significance lies in providing an alternative intervention for individuals who cannot benefit from exercise (such as the elderly or those with chronic diseases).
O-304 increases glucose uptake in skeletal muscle, reduces β-cell stress, and promotes β-cell rest in diet-induced obese mice. In a phase IIa proof-of-concept clinical trial in type 2 diabetes (T2D) patients treated with metformin, O-304 reduced fasting blood glucose levels and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).