NNMTi Peptide

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[ Ohter Name ] NNMTi; NNMT Inhibitor; Nicotinamide N-methyltransferase Inhibitor
[ CAS NO. ] 42464-96-0
[ Molecular Formula ] C10H11IN2
[ Molecular Weight ] 286.11
[ Appearance ] Brown to Reddish Brown Powder
[ Purity ] 99 %

[ Function ]
1. Can promote myoblast differentiation;
2. Inhibit tumor growth and metastasis;
3. Enhance the fusion and regeneration ability of muscle stem cells in aged mice;
4. Increase NAD+ levels and promote anti-aging metabolism;

About NNMTi Peptide
NNMTi is an inhibitor of nicotinamide N-methyltransferase (IC50 = 1.2 μM), selectively binding to the NNMT substrate binding site residues. It can induce myoblast differentiation in vitro and enhance the fusion and regeneration capacity of muscle stem cells in aged mice.
NNMTi exhibits a significant effect in promoting myoblast differentiation. Myoblasts are important cell types in muscle tissue, possessing the potential to differentiate into muscle fibers, which are crucial for muscle formation and repair. The mechanism of action of NNMTi may involve regulating signaling pathways related to myoblast differentiation, such as Wnt, Notch, or MyoD, which play a central role in regulating muscle cell proliferation, differentiation, and fusion. By inhibiting NNMT, NNMTi may indirectly promote the activation or inhibition of these pathways, thereby accelerating the myoblast differentiation process.
NNMTi also shows a significant promoting effect on muscle stem cells in aged mice. With age, the number and function of muscle stem cells gradually decline, leading to reduced muscle regeneration capacity, which is one of the main reasons for muscle atrophy and decreased strength in the elderly. However, the intervention of NNMTi seems to reverse this trend. Experimental results show that NNMTi can enhance the fusion and regeneration capacity of muscle stem cells in aged mice, meaning it has the potential to become a potential drug for treating age-related muscle atrophy.
This discovery of NNMTi not only provides a new perspective for understanding the role of NNMT in muscle development and regeneration but also opens the way for developing new therapies for muscle degenerative diseases. Through further research, scientists are expected to reveal the specific mechanisms by which NNMTi promotes muscle stem cell differentiation and regeneration, and design more precise and effective treatment strategies based on these findings. In addition, NNMTi may have other potential applications, such as in sports recovery, muscle injury repair, and anti-aging drug development. Its broad application prospects are worth further exploration and development.

[ Package ] 5g/Bag, 10g/Bag, 50g/Bag
[ Storage ] Store in a dry, dark place.
[ Shelf life ] 2 years if stored properly.
[ Remark ] For research purposes only. Not for human or animal use.