Niraparib
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[ Other Name ] Niraparib; MK-4827
[ CAS NO. ] 1038915-60-4
[ Molecular Formula ] C19H20N4O
[ Molecular Weight ] 320.396
[ Appearance ] White Powder
[ Purity ] ≥98%
About Niraparib
MK-4827 (Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8nM/2.1nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.
Niraparib is the world's first PARP inhibitor approved for first-line maintenance treatment of ovarian cancer in all patient populations. This means that patients can benefit from niraparib treatment regardless of whether they have a BRCA gene mutation.
It is used to treat recurrent epithelial ovarian cancer, fallopian tube cancer, and primary peritoneal cancer that are responsive to platinum-based chemotherapy.
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