Motixafortide

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[ CAS No. ] 664334-36-5
[ Molecular Formula ] C97H144FN33O19S2
[ Molecular Weight ] 2159.55
[ Appearance ] White Powder
[ Purity ] ≥98%

[ Function ]
By blocking the binding of the CXCR4 receptor to its ligand, CXCL12, stem cells are released from the bone marrow into the peripheral blood, significantly increasing the yield of collected CD34+ cells.

About Motixafortide
Motixafortide is a synthetic cyclic peptide composed of 14 amino acids; it functions as an antagonist of the CXCR4 chemokine receptor and is also classified as a hematopoietic stem cell mobilizer.
In the fields of oncology and regenerative medicine, Motixafortide is rapidly emerging as an innovative CXCR4 antagonist with significant potential for cancer treatment. By specifically binding to the CXCL12/CXCR4 axis, Motixafortide plays a critical role in the mobilization of hematopoietic stem cells for transplantation and offers multifaceted benefits in anticancer therapy.
Motixafortide has shown significant research progress across several areas. In the context of hematopoietic stem cell mobilization, it has demonstrated superiority over standard mobilizing agents by more effectively mobilizing peripheral blood stem cells (PBSCs), positioning it as a potential drug of choice prior to hematopoietic stem cell transplantation. In cancer treatment, given that CXCR4 is overexpressed in various types of malignant tumors, Motixafortide targets this receptor to inhibit the metastasis and spread of cancer cells; it is currently being evaluated for its anticancer efficacy in multiple clinical trials.