Mannitol
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[ CAS NO. ] 69-65-8
[ Molecular Formula ] C6H14O6
[ Molecular Weight ] 182.172
[ Appearance ] White Crystalline Powder
[ Function ]
1. Reduce intracranial pressure and cerebral edema;
2. Lower intraocular pressure; it can rapidly reduce eye pressure to protect the optic nerve;
3. Prevent and treat acute kidney injury;
4. Adjunctive treatment for tissue edema; it helps alleviate edema and relieve pain;
5. Promote the excretion of toxins; it accelerates the elimination of toxins via the kidneys;
[ Application ]
1. Pharmaceutical
Mannitol serves as an effective diuretic in medicine, used to lower intracranial and intraocular pressure. It also functions as a therapeutic agent for renal conditions and dehydration, a sugar substitute, and an excipient or diluent for solid and liquid pharmaceutical formulations.
2. Food Industry
Among sugars and sugar alcohols, mannitol exhibits the lowest hygroscopicity and possesses a pleasant, refreshing sweetness. It is used to prevent sticking in products such as maltose, chewing gum, and rice cakes, and serves as an anti-sticking powder for pastries. Additionally, it acts as a low-calorie, low-sugar sweetener in foods designed for diabetics and health-conscious consumers.
3. Other Industrial Applications
In the plastics industry, mannitol is used to produce rosin esters and synthetic glycerin resins, as well as explosives and detonators (such as nitromannitol). It is also employed in chemical analysis for the determination of boron and in biological testing as a bacterial culture medium.
About Mannitol
Mannitol is used clinically to reduce acutely raised intracranial pressure until more definitive treatment can be applied, e.g., after head trauma. It is also used to treat patients with oliguric renal failure. Mannitol can also be used to open the blood-brain barrier by temporarily shrinking the tightly coupled endothelial cells that make up the barrier. Mannitol is also used as a sweetener for people with diabetes, and in chewing gums.
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