Madecassic Acid

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[ Other Name ] Madecassic Acid; Brahmic Acid
[ Plant Source ] Centella asiatica
[ CAS NO. ] 18449-41-7
[ Molecular Formula ] C30H48O6
[ Molecular Weight ] 504.708
[ Appearance ] Light Yellow to White Powder
[ Purity ] HPLC≥98%

[ Function ]
1. It possesses inhibitory effects on iNOS, COX-2, TNF-α, IL-1beta, and IL-6, and reduces inflammatory responses by downregulating NF-κB activation;
2. It inhibits the production of LPS-induced nitric oxide (NO), prostaglandin E2, TNF-α, and IL-1β, exhibiting significant anti-inflammatory effects;
3. It inhibits lipid peroxidation, upregulates cell viability, significantly improves H2O2-induced endothelial cell apoptosis, and reduces intracellular Caspase-3 activity;
4. It lowers plasma fibrinogen and triglyceride levels, as well as reactive oxygen species (ROS) levels in the heart and kidneys;
5. It has anti-cancer effects, prevents and treats coronary heart disease, myocardial infarction, cerebral thrombosis, and cerebral infarction, and enhances memory;
6. It improves post-minimally invasive surgery recovery by enhancing epidermal barrier function;
7. It inhibits free radical damage to collagen fibers and delays wrinkle formation;
8. It reduces the expression of pro-inflammatory factors such as TNF-α, alleviating skin irritation.

[ Application ]
1. Pharmaceutical field:
It has anti-inflammatory effects, promotes the proliferation of dermal fibroblasts to form epithelium, promotes angiogenesis, stimulates endothelial cell growth, and promotes wound healing.
2. Cosmetics field:
Added as an active ingredient to skincare products, it has antioxidant and skin whitening effects and is commonly found in anti-aging formulations.
3. Scientific research reagents:
Used for content determination, pharmacological experiments, and drug screening, such as in depression and cancer research.

About Madecassic Acid
Madecassic acid is an effective active ingredient found in Centella asiatica. Studies have shown that it possesses various pharmacological activities, including antioxidant, antidepressant, antibacterial, and immunomodulatory effects, and especially exhibits significant inhibitory effects on tumor cells. It is widely used in the pharmaceutical and cosmetics industries.
In the field of health supplements, Madecassic acid is widely used for its anti-inflammatory and wound-healing properties, particularly in improving skin inflammation, accelerating wound healing, and reducing scar formation. Additionally, it possesses other health benefits, such as regulating the immune system and lowering blood sugar and lipid levels, thus playing a positive role in maintaining overall health.
In the pharmaceutical field, Madecassic acid is used to treat various diseases due to its unique pharmacological effects. For example, it can be used to treat skin inflammations, burns, ulcers, and other skin conditions, as well as to promote bone fracture healing and soft tissue repair. Its anti-inflammatory and antioxidant effects also help reduce inflammatory responses and alleviate symptoms such as pain and swelling.