Lirucitinib

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[ CAS NO. ] 2458115-78-9
[ Molecular Formula ] C16H25N5OS
[ Molecular Weight ] 335.47
[ Appearance ] White Powder
[ Purity (HPLC) ] >98%

[ Function ]
For the control of allergic pruritus and atopic dermatitis in dogs.

About Lirucitinib
Lirucitinib is a JAK inhibitor specifically designed for dogs that targets the cellular signaling pathways responsible for pruritus (itching) and allergic inflammation. It acts exclusively on allergic itching and is ineffective against inflammation caused by bacterial or fungal infections or physical trauma.
By precisely inhibiting the signaling of various pruritogenic, pro-inflammatory, and allergic cytokines that rely on JAK1 enzyme activity, Lirucitinib blocks the activation and propagation of abnormal immune responses at the source. It effectively breaks the vicious cycle of "itching–scratching–worsening inflammation–skin damage" in canine skin. In clinical practice, Lirucitinib rapidly alleviates overt symptoms such as intense itching, frequent scratching, and skin redness and inflammation. Simultaneously, it effectively ameliorates secondary damage—including skin ulceration, hair loss, and secondary infections—caused by persistent scratching, thereby achieving a therapeutic outcome that combines symptom relief with skin repair.