Larazotide

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[ Sequence ] H-Gly-Gly-Val-Leu-Val-Gln-Pro-Gly-OH
[ CAS No. ] 258818-34-7/881851-50-9 (acetate)
[ Molecular Formula ] C32H55N9O10
[ Molecular Weight ] 725.845
[ Purity ] 98% by HPLC

[ Function ]
1. It may help reduce symptoms and improve the integrity of the intestinal barrier in individuals with celiac disease.
2. It may potentially reduce the immune response to gluten and decrease the damage to the small intestine caused by gluten exposure.
3. It may help reduce abdominal pain, improve stool consistency, and alleviate other symptoms associated with IBS-D.

About Larazotide
Larazotide acetate is an investigational drug that has been studied for its potential therapeutic use in various gastrointestinal conditions. It belongs to a class of drugs called tight junction modulators.
Larazotide works by modulating the tight junctions, helping to restore their normal function and reduce the permeability of the intestinal barrier. By doing so, it aims to reduce the passage of toxins and antigens from the gut into the bloodstream, potentially alleviating symptoms and inflammation associated with certain gastrointestinal conditions.
In the context of celiac disease, larazotide has been studied as an adjunctive therapy along with a gluten-free diet. Clinical trials have shown mixed results regarding its effectiveness in reducing symptoms and gluten-induced damage to the small intestine. 
For IBS-D, larazotide has shown some promising results in reducing symptoms such as abdominal pain, diarrhea, and bloating in certain clinical trials.