α-Ketoglutaric Acid

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[ Other Name ] 2-Ketoglutaric acid; alpha-Ketoglutaric acid
[ CAS No. ] 328-50-7
[ Molecular Formula ] C5H6O5
[ Molecular Weight ] 146.098
[ Appearance ] White Fine Powder
[ Purity ] 99%

[ Function ]
1. Promotes energy metabolism and mitochondrial function;
2. Alleviates muscle soreness and reduces post-exercise fatigue by accelerating lactate clearance and restoring ATP levels;
3. Delays cellular aging by activating the AMPK pathway;
4. Reduces the oxidative loss of branched-chain amino acids (BCAAs), helping to maintain muscle mass;
5. Neutralizes free radicals and mitigates damage from oxidative stress;
6. Promotes anabolism, supporting muscle repair and growth;
7. Serves as a precursor to glutamine, facilitating protein synthesis and muscle repair;
8. Enhances the cellular antioxidant defense system by activating the Nrf2 pathway, thereby reducing oxidative damage to DNA and proteins;
9. May improve exercise endurance and accelerate post-exercise muscle recovery;

About α-Ketoglutaric Acid
α-Ketoglutaric Acid is a 2-oxocarboxylic acid (2-OCA) that is produced as a metabolite in the Krebs cycle.
α-Ketoglutaric Acid serves a variety of physiological functions within living organisms. It acts as an energy donor, a precursor for amino acid synthesis, and a cellular signaling molecule, while also functioning as a regulator of epigenetic processes. Furthermore, it plays roles in modulating nitrogen metabolism, promoting growth, regulating energy metabolism, maintaining intestinal health, enhancing immune function, and improving bone quality.
α-Ketoglutaric Acid is a multifunctional biological molecule that not only participates directly in oxidative energy production and various chemical synthesis processes within the body, but also plays a key role in regulating energy metabolism, promoting muscle growth, enhancing protein synthesis, improving bone health, facilitating weight management, and maintaining intestinal health. It is widely utilized across the pharmaceutical, cosmetic, and agricultural sectors; for instance, it serves as a dietary supplement and nutritional fortifier for both humans and animals. Furthermore, it is employed in reagents for liver function testing, as an aid to improve the success rate of rapid pulmonary surgeries, as a drug carrier, and as an agent to enhance drought resistance in crops.