Honokiol

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[ Plant Source ] Magnolia officinalis
[ CAS NO. ] 35354-74-6
[ Molecular Formula ] C18H18O2
[ Molecular Weight ] 266.334
[ Appearance ] White Powder
[ Purity ] ≥98%

[ Function ]
1. Neuroprotective and anxiolytic effects;
2. Improves cognitive function, with potential benefits for Alzheimer's and Parkinson's diseases;
3. Anti-obesity and metabolic regulation;
4. Anti-inflammatory and antioxidant effects;
5. Antibacterial and antiviral effects;
6. Anti-tumor effects;
7. Anti-aging effects;

[ Key Application Areas ]
Pharmaceutical Field
1. Development of therapeutic drugs for anxiety, depression, insomnia, Alzheimer's disease, and Parkinson's disease.
2. Use as chemotherapy sensitizers or targeted therapeutic agents, either alone or in combination.
3. Treatment and prevention of atherosclerosis, hypertension, and myocardial ischemia.
4. Treatment of chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

About Honokiol
Honokiol is a biphenolic compound extracted from the bark of magnolia officinalis or magnolia obovata. It exhibits pharmacological activities such as anti-inflammatory, antioxidant, anti-tumor, and neuroprotective effects, and is widely used in traditional Chinese medicine and modern drug development.
Honokiol significantly alleviates generalized anxiety disorder, sleep disorders, and stress-related disorders, without the dependency or cognitive impairment side effects associated with traditional benzodiazepines.
Honokiol demonstrates significant inhibitory effects against various malignant tumors—including breast, lung, colon, and prostate cancers, as well as glioblastoma—while exhibiting low toxicity toward normal cells.
Honokiol possesses potent free-radical scavenging capabilities, with antioxidant activity far exceeding that of Vitamin E. It reduces the production of pro-inflammatory factors by inhibiting key inflammatory signaling pathways such as NF-κB, MAPK, and STAT3, and has shown excellent anti-inflammatory efficacy in animal models of arthritis, colitis, and neuroinflammation.
Honokiol improves vascular endothelial function, inhibits the abnormal proliferation of vascular smooth muscle cells, and helps prevent atherosclerosis. It also exhibits anti-platelet aggregation, antithrombotic, and antihypertensive properties, offering protective effects against cardiovascular diseases such as coronary heart disease and myocardial ischemia.
Honokiol inhibits various drug-resistant pathogens, including methicillin-resistant staphylococcus aureus (MRSA) and candida albicans. It also demonstrates inhibitory effects against viruses such as influenza, herpes simplex, and HIV.
Honokiol activates the AMPK signaling pathway, promotes fatty acid oxidation, and inhibits lipogenesis. By regulating the expression of genes related to lipid metabolism, it ameliorates obesity and insulin resistance induced by a high-fat diet.