Folinate Calcium Pentahydrate

[ CAS NO. ] 6035-45-6;1492-18-8
[ Molecular Formula ]  C20H21CaN7O7
[ Molecular Weight ]  511.5
[ Purity ]  >=95%
[ Appearance ] White to yellowish powder
[ Application ] Anti-Cancer Drug
[ Uses ] 
1.It is mainly used as the antidote of folic acid antagonists (such as methotrexate,pyrimethamine or trimethoprim, etc.).
2.It can be used for the prevention of severe toxicity after excessive or large doses administration of methotrexate.
3.The megaloblastic anemia caused by folic acid deficiency.
4.In combination with fluorouracil, it is used for the treatment of advanced colon cancer and rectal cancer.
About Folinate calcium pentahydrate
Folinate calcium pentahydrate is a folate-reduced formylated derivative. It is an activated form of folic acid in the body. It acts similarly to folic acid and is mainly used as the antidote of folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.). It can also be used for the prevention of severe toxicity after excessive or large doses administration of methotrexate, and as an adjuvant for anticancer drugs.