Equol

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[ Other Name ] 4',7-Isoflavandiol; S-Equol
[ Herb Source ] Soybeans
[ CAS No. ] 531-95-3
[ Molecular Formula ] C15H14O3
[ Molecular Weight ] 242.274
[ Appearance ] White Crystalline Powder

[ Function ]
1. Estrogen-like effects: Acts as a selective estrogen receptor modulator (SERM) with high affinity for ERβ.
2. Promotes breast health: Equol supports the healthy growth and function of breast cells, potentially helping to reduce the risk of breast cancer.
3. Alleviates menopausal symptoms: For women, Equol can help alleviate menopausal symptoms, such as irritability and mood swings.
4. Antioxidant activity: May help combat oxidative stress and reduce cellular damage caused by free radicals.
5. Impact on bone health: May offer potential benefits in preventing bone diseases, such as osteoporosis.
6. Antimicrobial activity: Exhibits inhibitory effects against common intestinal bacteria and fungi.
7. Cardiovascular health: May exert neuroprotective effects against HIV-associated chronic neurocognitive disorders.

About Equol
Equol (S-Equol) is a novel bioactive plant compound that enhances the antioxidant defense system through multiple mechanisms while simultaneously reducing oxidative stress and inflammation, thereby offering potential anti-pollution effects.
Equol is a phytoestrogenic compound produced through the metabolic breakdown of soy isoflavones by intestinal microbiota; it offers a range of potential health benefits, including the alleviation of menopausal symptoms and a reduction in the risk of breast cancer.
As a selective estrogen receptor modulator (SERM), Equol exerts a dual regulatory effect by binding to estrogen receptor beta (ERβ). In breast tissue, Equol inhibits excessive estrogenic stimulation, thereby lowering the risk of breast cancer. Conversely, within the skeletal and cardiovascular systems, it mimics the effects of estrogen, helping to improve bone density and alleviate hot flashes in postmenopausal women.
Equol possesses a molecular structure similar to that of endogenous human estrogen, enabling it to bind to estrogen receptors. In cases of estrogen deficiency—such as during menopause—it acts as an estrogen agonist, helping to alleviate menopausal symptoms, osteoporosis, and related issues. Conversely, when endogenous estrogen levels are excessive, it competes with estrogen for receptor binding sites, thereby reducing the risk of estrogen-related diseases, such as breast cancer and uterine fibroids.
Equol serves as a superior antioxidant, demonstrating greater antioxidant potency than either Vitamin C or Vitamin E. It effectively scavenges free radicals and delays cellular senescence; furthermore, it stimulates the activity of antioxidant and detoxification enzymes while inhibiting biomarkers associated with skin aging, thereby exerting significant anti-aging effects on the skin.