D-Mannitol

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[ CAS NO. ] 69-65-8
[ Molecular Formula ] C6H14O6
[ Molecular Weight ] 182.172
[ Appearance ] White Crystalline Powder
[ Purity ] ≥98% (HPLC)

[ Function ]
1. Lowering blood glucose
Reduces glucose levels in the body by inhibiting the breakdown of hepatic glycogen in the liver and promoting the uptake and utilization of glucose by peripheral tissues.
2. Improving glucose tolerance
Enhances the body's sensitivity to insulin and accelerates the entry of glucose into cells for metabolism, helping to control postprandial (after-meal) hyperglycemia.
3. Promoting weight loss
Through its osmotic diuretic effect, it can increase energy expenditure to a certain extent, thereby facilitating weight loss.
4. Diuretic effect
Promotes the excretion of water through the kidneys, resulting in a diuretic effect.
5. Preventing renal tubular damage
Because the reabsorption of this substance in the renal tubules requires a significant amount of sodium ions, it helps prevent damage to the renal tubules that might otherwise be caused by sodium deficiency.

[ Application ]
1. Pharmaceutical
Tablet and capsule excipient, bulking agent, formulation aid
2. Food and beverage
Sweetener and formulation ingredient

About D-Mannitol
D-Mannitol is a naturally occurring sugar alcohol (polyol) found in various plants, algae, and fungi. It is widely used in the pharmaceutical, food, and healthcare industries because of its low hygroscopicity, pleasant sweetness, and useful physical properties.
In pharmaceutical manufacturing, D-Mannitol is particularly valued as an excipient in tablets, capsules, and orally disintegrating formulations. Depending on its grade and specifications, it can serve as a diluent, bulking agent, sweetener, or stabilizing ingredient.
D-Mannitol not only provides sweetness but also helps maintain the desired mouthfeel and texture in food and beverages, better aligning them with consumer taste preferences.