Corynoxine

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[ CAS NO. ] 6877-32-3
[ Molecular Formula ] C22H28N2O4
[ Molecular Weight ] 384.47
[ Appearance ] White Powder
[ Purity (HPLC) ] >98%

[ Function ]
1. Neuroprotective effects:
It promotes cellular autophagy and aids in the clearance of abnormal proteins, demonstrating the potential to alleviate pathological changes in models of Alzheimer's disease and Parkinson's disease.
2. Antitumor activity:
It targets the NQO1 protein and activates the tumor suppressor protein PP2A, thereby inhibiting the growth of various tumor cells, such as those of lung and breast cancers.

About Corynoxine
Corynoxine is a tetracyclic oxindole alkaloid isolated from uncaria rhynchophylla. As a natural autophagy enhancer, it promotes the clearance of α-synuclein via the Akt/mTOR pathway, making it a subject of significant interest in research regarding the prevention and treatment of Parkinson's disease. In models of Parkinson's disease and Alzheimer's disease, it effectively induces autophagy by activating pathways such as TFEB/TFE3 or SIRT1. This facilitates the clearance of toxic, misfolded proteins accumulating within neurons, thereby mitigating neuronal damage and improving motor and cognitive functions in animal models.