Chlorogenic Acid

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[ The source of the plant ]
Honeysuckle subject Lonicera japonica. Eucommia department Eucommia ulmoides Oliver
[Synonyms ] 3-Caffeoylquinic acid
[ CAS NO. ] 202650-88-2
[ Molecular Formula ] C16H18O9
[ Molecular Weight ] 354.34
[ Appearance ] Light White Powder
[ Main Specification ] 10%-98%

[ Function ]
1. Blood Sugar Regulation:
Helps regulate blood glucose levels, improves insulin resistance, and reduces the risk of Type 2 diabetes.
2. Antioxidant Effects:
Protects cellular health and minimizes oxidative damage by scavenging free radicals and inhibiting lipid peroxidation.
3. Anti-Aging Effects:
Reduces cellular apoptosis and DNA fragmentation, while lowering levels of reactive oxygen and nitrogen species.
4. Anti-Inflammatory Effects:
Alleviates tissue inflammation by inhibiting inflammatory cytokines (such as TNF-α), thereby helping to delay skin photoaging.
5. Lipid Metabolism Regulation:
Promotes lipolysis and reduces hepatic lipid accumulation by activating the AMPK signaling pathway.
6. Neuroprotective Effects:
Reduces the deposition of beta-amyloid proteins, improves cognitive function, and holds potential therapeutic value for Parkinson's disease.
7. Cardioprotective Effects:
Lowers blood lipid and cholesterol levels, thereby helping to prevent cardiovascular diseases.
8. Weight Loss Effects:
Inhibits the synthesis and accumulation of fat while promoting fat breakdown and metabolism, leading to a reduction in body weight.

COA of Chlorogenic Acid
Odor: Light smell and slight taste
Specification: Chlorogenec acid >98%
Melting point range: 208℃
Sieve analysis: 100% through 80 mesh
Residue on ignition: 0.30%
Residual Solvents: Eur.Pharm.
Heavy metals: <10PPM
Pesticides: Negative
Total Plate Count: <1000CFU/gm
Yeast & Mold: <100CFU/gm
Salmonella: Negative
E.Coli : Negative

About Chlorogenic Acid
Chlorogenic acid is a family of naturally occurring organic compounds. These are esters of cinnamic acids and (-)-quinic acid.It is an important biosynthetic intermediate.It also is one of the phenols found in coffee as well as many other plants.This compound, long known as an antioxidant, also slows the release of glucose into the bloodstream after a meal.
Chlorogenic acid is a type of polyphenol widely recognized as a potent natural antioxidant; indeed, it serves as the primary active ingredient in many antioxidant-focused health supplements.
Researchers have discovered that chlorogenic acid can mitigate apoptosis in retinal neurons caused by hypoxia or excessive levels of carbon monoxide. Since chlorogenic acid effectively reduces retinal cell death, it holds potential for preventing pathological conditions associated with retinal degeneration.
Chlorogenic acid has been shown to significantly reduce body weight, visceral fat mass, plasma levels of leptin and insulin, triglyceride levels in the liver and heart, as well as cholesterol levels in adipose tissue and the heart. Furthermore, chlorogenic acid specifically demonstrates a significant capacity to lower triglyceride content within adipose tissue.
The mechanism by which chlorogenic acid regulates blood glucose involves inhibiting the expression and activity of hepatic glucose-6-phosphatase. This action reduces hepatic steatosis (fatty liver), improves lipid profiles, and enhances glucose uptake in skeletal muscle, thereby leading to improvements in blood glucose levels, glucose tolerance, insulin sensitivity, and dyslipidemia.
Chlorogenic acid exhibits inhibitory and bactericidal effects against a wide range of pathogenic bacteria. Experimental studies indicate that its primary mechanism for inhibiting pathogens involves disrupting their sugar metabolism; this leads to an energy deficit within the bacteria, thereby arresting their growth. Additionally, chlorogenic acid can reduce bacterial populations by inhibiting the synthesis of bacterial flagella.
Research also indicates that chlorogenic acid possesses antiviral properties. Researchers have identified it as a potentially effective compound against the human immunodeficiency virus (HIV), suggesting it may play a significant role in the development of future antiviral therapies for HIV.