Ac-SDKP Peptide

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[ Other Name ] Goralatide
[ Sequence ] Ac-Ser-Asp-Lys-Pro-OH
[ CAS NO. ] 486-66-8
[ Molecular Formula ] C20H33N5O9
[ Molecular Weight ] 487.5
[ Appearance ] White Powder
[ Purity ] ≥95% (HPLC)

[ Function ]
1. Anti-inflammatory;
2. Antifibrotic;
3. Can improve myocardial remodeling and reduce myocardial damage;
4. Has the effects of constricting blood vessels and promoting cell proliferation;
5. Inhibit the renin-angiotensin system, reducing kidney inflammation and fibrosis, and has a certain protective effect on chronic kidney disease;

About Ac-SDKP Peptide
Ac-SDKP is a natural tetrapeptide with anti-inflammatory and anti-fibrotic properties. It is widely distributed in mammalian organs, plasma, urine, and circulating monocytes. The peptide is hydrolyzed by angiotensin-converting enzyme (ACE) and has a half-life of 4.5 minutes in the circulation. ACE inhibitor treatment significantly increases the plasma concentration of Ac-SDKP, and the protective effects of some ACE inhibitors are reported to be mediated by increased Ac-SDKF concentrations. In animal diseases with hypertension, as well as cardiovascular and renal diseases, Ac-SDKP reduces inflammatory cell infiltration and collagen deposition in the heart, kidneys, lungs, and liver. The peptide has potential applications in the treatment of various inflammatory and fibrotic diseases.