(7S)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride

(7S)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride

[ Synonyms ]  (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride; J-500399; (S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine 
[ CAS NO. ] 866783-13-3 
[ Molecular Formula ] C12H18ClNO2
[ Molecular Weight ] 243.731 
[ Appearance ] White to off-white powder
[ Boiling Point ] 338.6ºC at 760 mmHg
[ Flash Point ] 158.6ºC
[ Purity ] 99.0%min
COA of (7S)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride
[ Item of analysis ]
Specific rotation(on dried basis,1% solution in methanol):  +18.35º
Identification: HPLC/UV
Total impurities: NMT 0.18%
Maximum single impurity: NMT 0.09%
Optical isomer:  0
Loss on Drying(Dry it at 105℃ in an electric air blowing drier till a constant weight:  0.07%
Assay(on dried basis, by titrition): 100.50%
About (7S)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride
(7S)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride is an intermediate used in preparation of Ivabradine which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node.



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