Shogaol
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[ Other Name ] Shogaol; 6-Shogaol
[ CAS No. ] 23513-13-5
[ Molecular Formula ] C17H24O3
[ Molecular Weight ] 276.376
[ Appearance ] Pale Yellow Powder
[ Function ]
1. Inhibits α-glucosidase activity and delays sugar absorption, helping to regulate postprandial blood glucose fluctuations;
2. Stimulates the gastric mucosa to secrete digestive enzymes, alleviating bloating and loss of appetite;
3. Reduces oxidative stress by scavenging free radicals and inhibits the expression of pro-inflammatory cytokines (such as IL-6 and TNF-α), potentially alleviating chronic inflammatory conditions like arthritis and enteritis;
4. Induces apoptosis in cancer cells and inhibits angiogenesis, thereby slowing the proliferation of tumor cells in cancers such as breast and colon cancer;
5. Activates TRPV1 receptors, dilating blood vessels and accelerating blood flow to alleviate issues such as cold hands and feet;
6. May enhance energy metabolism by modulating the AMPK pathway, indirectly supporting weight management;
About Shogaol
6-Shogaol is an active chemical compound isolated from fresh and dried ginger. It exhibits various biological activities, including anti-inflammatory and anti-atherosclerotic effects; therapeutic potential for gastric ulcers, cardiovascular diseases, and dementia; the ability to restore motor function following bone marrow injury; and anti-hepatitis viral activity.
By inhibiting the release of inflammatory mediators (such as NF-κB and COX-2), 6-shogaol reduces inflammatory responses, thereby helping to alleviate chronic inflammatory conditions like arthritis and enteritis. Additionally, it scavenges free radicals and enhances the activity of endogenous antioxidant enzymes, protecting cells from oxidative damage, delaying aging, and lowering the risk of chronic diseases.
6-shogaol stimulates gastric acid secretion and accelerates gastrointestinal motility, helping to relieve symptoms such as loss of appetite, bloating, and nausea. Research indicates that it also inhibits the growth of pathogenic intestinal bacteria and regulates gut microbiota balance, offering supportive benefits for functional dyspepsia and mild food poisoning.
By blocking pain signal transmission (such as through the inhibition of TRPV1 receptors), 6-shogaol alleviates discomfort associated with migraines and muscle soreness. Furthermore, its antioxidant properties reduce neuronal damage; animal studies have demonstrated its potential protective effects against neurodegenerative diseases like Alzheimer's and Parkinson's.
6-shogaol activates metabolic enzymes such as AMPK, promoting lipolysis and inhibiting lipogenesis, thereby assisting in the regulation of blood glucose and lipid levels. Some studies suggest that long-term, moderate intake may help improve metabolic syndrome conditions—such as obesity and diabetes—though this should be combined with proper diet and exercise.
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