Tocofersolan

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[ Other Name ] Tocophersolan; Tocopherol Polyethylene Glycol Succinate; TPGS; Vitamin E-TPGS
[ CAS No. ] 9002-96-4
[ Molecular Formula ] (C2H4O)nC33H54O5
[ Appearance ] Off-white or yellowish waxy solid
[ Assay ]≥25.0%

[ Function ]
1. Antioxidant Protection:
As a derivative of Vitamin E, it inherently possesses the skincare benefits of tocopherol; it scavenges free radicals, protects the skin from oxidative damage, and helps delay the signs of aging.
2. Stabilization of Active Ingredients:
Its antioxidant properties also serve to protect other easily degradable ingredients within a formulation, preventing their deactivation and enhancing the overall stability of the product.
3. Enhanced Absorption:
Featuring an amphiphilic structure, it increases the fluidity of skin lipids, thereby facilitating the penetration of active ingredients into skin cells and aiding the delivery of compounds—such as Vitamin C—deep into the skin.
4. Solubilization and Emulsification:
Acting as a non-ionic surfactant, it significantly improves the aqueous solubility of sparingly soluble ingredients, resulting in a more uniform formulation and resolving the challenges associated with incorporating oil-soluble components.
5. Increased Retention:
It inhibits the efflux of ingredients from the skin, thereby substantially increasing the retention levels of active compounds within the skin tissue; this boosts bioavailability and enhances the overall efficacy of the skincare product.

About Tocofersolan
Tocofersolan is a water-soluble derivative of Vitamin E. Possessing both a lipophilic Vitamin E moiety and a long hydrophilic polyethylene glycol chain, it exhibits excellent surfactant properties and water solubility. Consequently, it is widely utilized in pharmaceutical formulation research as a solubilizer, absorption enhancer, emulsifier, plasticizer, and carrier for delivery systems involving poorly water-soluble or lipophilic drugs—such as solid dispersions, as well as carriers for ocular and intranasal drug delivery.
In cosmetic applications, Tocofersolan primarily functions as an antioxidant, penetration enhancer, and solubilizer; as a water-soluble derivative of Vitamin E, it facilitates the enhanced absorption and stabilization of active ingredients within the skin. It effectively neutralizes free radicals and mitigates skin cell damage caused by environmental stressors, UV radiation, and other factors. By shielding the skin from oxidative stress, it helps to delay the skin aging process.
Furthermore, Tocofersolan demonstrates exceptional moisturizing capabilities. The presence of both hydrophilic and lipophilic groups within its molecular structure enables it to form emulsions or microemulsions. These structures facilitate the formation of a protective film on the skin's surface, thereby locking in moisture and preventing dryness and dehydration. This property is crucial for maintaining skin softness and elasticity, particularly in dry or cold environments.
Tocofersolan also possesses the ability to enhance skin permeability. In cosmetic formulations, it serves as a penetration enhancer, facilitating the more efficient passage of other active ingredients through the stratum corneum—the outermost layer of the skin—to reach deeper layers where they can exert their therapeutic effects. This characteristic renders Tocofersolan particularly valuable in functional cosmetics targeting specific concerns—such as skin brightening and spot reduction—as it boosts the absorption efficiency of other whitening agents within the formulation (e.g., Vitamin C derivatives and arbutin), thereby amplifying the overall brightening efficacy.
Moreover, Tocofersolan exhibits notable stability and compatibility. It is compatible with a wide array of cosmetic raw materials and is resistant to undergoing chemical reactions that could lead to product degradation, thereby ensuring the overall quality and stability of the cosmetic product.
In practical cosmetic applications, Tocofersolan is frequently incorporated into a diverse range of products, including face creams, lotions, and serums. For instance, in skin-whitening and spot-correcting cosmetics, Tocophersolan works synergistically with other whitening agents—leveraging its multifaceted properties of antioxidation, moisturization, and enhanced skin penetration—to help consumers achieve a brighter complexion and diminish the appearance of dark spots. Furthermore, thanks to its excellent stability and compatibility, Tocophersolan has become a preferred ingredient for many high-end cosmetic brands.