Madecassoside

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[ Other Name ] Redermic, Asiaticoside A
[ Herb Source ] Centella asiatica (L.) Urban
[ Cas No. ] 34540-22-2
[ Molecular Formula ] C48H78O20
[ Formula Weight ] 975.132
[ Assay ] ≥95%
[ Appearance ] White Powder

[ Function ]
1. Inhibits UV-induced melanin synthesis and melanosome transfer, thereby improving pigmentation;
2. Accelerates wound healing and inhibits TGF-β receptor expression, thereby reducing scar proliferation;
3. Promotes the synthesis of Type I and Type III collagen, enhances the stratum corneum's water-retention capacity, and repairs damage to the skin barrier;
4. Scavenges free radicals, mitigates oxidative stress damage, and protects cells from oxidative injury;
5. Significantly increases collagen secretion, thereby delaying skin aging;
6. Inhibits the production of the pro-inflammatory cytokine IL-1β, thereby alleviating skin inflammatory responses;
7. Promotes hyaluronic acid secretion and enhances skin hydration;
8. Exhibits superior ROS-scavenging capabilities, protecting cells from oxidative damage;
9. Stimulates fibroblast proliferation, accelerates collagen synthesis, and promotes wound healing;
10. Provides protective effects for the joints, cardiovascular system, and nervous system;

About Madecassoside
Madecassoside is a major bioactive triterpene saponin extracted from Centella asiatica. It is structurally similar to asiaticoside but features an additional hydroxyl group, which contributes to its enhanced antioxidant and anti-inflammatory profile. Chemically, it is madecassic acid glycosylated with sugars, making it highly water-soluble and suitable for topical skincare formulations.
Madecassoside excels at calming irritated, sensitive, or inflamed skin. It downregulates pro-inflammatory cytokines (e.g., TNF-α, IL-6) and mediators like nitric oxide, helping reduce redness, itching, and discomfort in conditions such as eczema, atopic dermatitis, rosacea, psoriasis-prone skin, or post-procedure irritation (e.g., after laser or exfoliation). It is particularly valued for barrier repair and recovery from environmental stressors or over-exfoliation.
Madecassoside stimulates production of type I and type III collagen in dermal fibroblasts, improving elasticity, firmness, and suppleness. It helps mitigate photoaging by reducing oxidative stress and inflammation.
Madecassoside often shows superior or faster anti-inflammatory/soothing effects and better antioxidant capacity due to its extra hydroxyl group; it may also edge out in hydration and direct melanin inhibition in some studies.