AHK-Cu

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[ Other Name ] AHK-Cu; Copper Tripeptide-3 Hydrochloride
[ Sequence ] Ala-His-Lys.Cu2+
[ CAS NO. ] 682809-81-0
[ Molecular Formula ] C14H26N6O8S2Cu
[ Molecular Weight ] 354.4
[ Appearance ] Blue Powder
[ Purity ] ≥98.0%

[ Function ] 
1. Promotes hair growth:
Activates the Wnt/β-catenin pathway, specifically awakening hair follicle stem cells and prolonging the hair growth phase.
Stimulates human hair follicle elongation and dermal papilla cell proliferation; commonly used to treat hair loss and improve scalp health.
2. Skin anti-aging and repair:
Activates the AMPK pathway, promoting collagen synthesis by fibroblasts and enhancing skin firmness.
Offers antioxidant and skin-repairing benefits, helping to reduce fine lines and dullness; frequently included in cosmetic products such as serums and moisturizers.

About AHK-Cu
At room temperature and atmospheric pressure, AHK-Cu appears as a loose, blue to blue-green powder; it is odorless, tasteless, free of visible mechanical impurities, and possesses good flowability. Slight clumping may occur during prolonged storage or upon exposure to moisture, but the powder can be restored by grinding without affecting its activity. Its color arises from the complexation between copper ions and the tripeptide chain; the intensity of the color correlates positively with purity and concentration—higher purity and concentration result in a deeper, richer color.
The core advantage of AHK-Cu is its potent ability to promote hair growth. Its mechanism of action primarily involves activating the proliferation and differentiation of hair follicle dermal papilla cells (DPCs), prolonging the hair follicle growth phase (anagen), and shortening the resting phase (telogen). Simultaneously, it upregulates hair growth-related genes (such as VEGF, IGF-1, and β-catenin), promotes angiogenesis and nutrient supply to hair follicles, inhibits apoptotic pathways, and reduces follicle degeneration. It also modulates androgen receptor (AR) expression and mitigates the inhibitory effects of dihydrotestosterone (DHT) on hair follicles. Consequently, it is widely used in various hair growth and anti-hair loss products and stands as a key ingredient for promoting hair growth in the beauty industry.
As a blue copper peptide derivative, AHK-Cu offers both skin repair and anti-aging benefits. It functions by promoting fibroblast proliferation and upregulating the production of Type I/III collagen, elastin, proteoglycans, and glycosaminoglycans, thereby improving skin elasticity and reducing wrinkles. It accelerates wound healing, minimizes scarring, repairs the skin barrier, enhances the water-retention capacity of the stratum corneum, and benefits sensitive skin. Additionally, its antioxidant properties scavenge free radicals, mitigate oxidative stress damage, inhibit melanocyte overactivation, even out skin tone, and brighten dull complexions.
Thanks to its multifaceted biological activities—including hair growth promotion, skin repair, and anti-inflammatory and antioxidant effects—as well as its high biocompatibility and low irritation, AHK-Cu is widely utilized in beauty and skincare, scientific research, and the production of pharmaceutical intermediates.

[ Storage ]
It is recommended to store the product in lyophilized form at -20°C, or refrigerated at 2–8°C and protected from light, to maintain its stability and efficacy.