Neohesperidin Dihydrochalcone

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[ Herb Source ] Citrus Aurantium L(Bitter Oranges)
[ CAS NO. ] 20702-77-6
[ Molecular Formula ] C28H36O15
[ Molecular Weight ] 612.58
[ Appearance ] White Powder

[ Product Features ]
1. High sweetness, low calorie content;
2. Slow onset of sweetness, long-lasting effect;
3. Good stability, non-toxic, and rapidly metabolized;

[ Function ]
1. NHDC reduces cellular damage by scavenging free radicals and inhibiting oxidative stress; it also modulates the expression of inflammatory cytokines (such as TNF-α and IL-6) to alleviate chronic inflammation.
2. NHDC improves insulin resistance, promotes glucose uptake, and lowers blood glucose levels; it also inhibits the activity of enzymes associated with adipogenesis, reduces lipid accumulation, and aids in weight management.
3. By reducing oxidative damage to the vascular endothelium and inhibiting platelet aggregation, NHDC improves vascular elasticity and helps prevent cardiovascular diseases such as atherosclerosis.
4. Its antioxidant properties mitigate hepatocyte damage and inhibit the progression of liver fibrosis, offering benefits for alcoholic or non-alcoholic fatty liver disease.
5. NHDC scavenges free radicals in the skin, promotes skin metabolism, reduces pigmentation, and moisturizes the skin, showing promise as a novel skin-whitening agent in cosmetics.
6. NHDC possesses flavoring properties, including sweetening, aroma enhancement, flavor enhancement, and bitterness masking.

[ Application ]
1. Food and Beverage:
Commonly used as a sweetener or flavor enhancer in fruit juices, dairy beverages, candies, chewing gum, baked goods, and low-calorie drinks; it helps improve sour and astringent tastes.
2. Animal Feed:
In May 2026, the EU approved its use as a feed additive for species such as piglets, fattening pigs, and calves; it enhances feed sweetness, thereby boosting animal appetite and growth rates.
3. Pharmaceuticals:
Can be used to manufacture raw materials for lipid-lowering and blood glucose-lowering drugs, hepatoprotective agents, and stomach medications.
4. Cosmetics:
Utilized in cosmetics for its antioxidant properties, aiding in skin whitening and the reduction of pigmentation.

About Neohesperidin Dihydrochalcone (NHDC)
Neohesperidin dihydrochalcone (NHDC) is a novel sweetener produced by the hydrogenation of neohesperidin, which is extracted from natural citrus plants. Characterized by high sweetness, a pleasant taste profile, a lingering aftertaste, low caloric content, non-toxicity, and good stability, it is currently one of the most notable new sweeteners and bitterness maskers, finding widespread application in the food and animal feed industries.
Neohesperidin dihydrochalcone (NHDC) is a high-intensity, low-calorie sweetener derived from a natural flavonoid compound through chemical modification. It offers various benefits—including antioxidant and anti-inflammatory properties, metabolic regulation, and cardiovascular and hepatic protection—and is widely used in the food and pharmaceutical industries.
NHDC does not undergo caloric conversion in the body; it is a low-calorie sweetener that exhibits physiological activities such as blood sugar and cholesterol reduction, as well as antioxidant properties. It is particularly suitable for use as a sugar substitute in health-oriented products, including functional foods, health supplements, and dietary supplements.