[ Synonyms ]4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione; 1,2-Diphenyl-3,5-dioxo-4-n-butylpyrazoline
[ CAS No. ] 50-33-9
[ Molecular Formula ] C19H20N2O2
[ Molecular Weight ] 308.38
[ Melting point ] 104-107 ºC
[ Water solubility ] <0.1 g/100 mL at 23.5 ºC
[ Appearance ] off-white powder
Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase). that is also a substrate for peroxidation by Cox.
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