[ Appearance ] white to almost white powder
Trichosanthin is a drug for heat-removing and swelling reducing.
Trichosanthin is a ribosome-inactivating protein and a kind of basic protein extracted from the roots of cucurbitaceae plants of the genus trichosanthes kirilowii trichosanthes kirilowii piece, belonging to the type Ⅰ Ribosome Inactivating protein (Ribosome Inactivating Proteins, RIPs). It is 56 % homologous to the A - chain of the double - stranded RIPs2 Ricin protein (Ricin). Trichosanthin is clinically used for the treatment of gynecologic diseases such as labor induction. In addition, due to its activity of N2 glycosidase, Trichosanthin can hydrolyze the N2C glycosidic bond of adenosine on position 4324 of 28SrRNA of ribosomes in eukaryotic cells, making ribosomes irreversible and thus inhibiting the synthesis of proteins.
Studies have shown that Trichosanthin has an inhibitory effect on DNA amplification of cancer cells. To HIV virus and many other viruses, it has different degrees of inhibition. Trichosanthin has been shown to damage the DNA of tumor cells and lead to apoptosis. Trichosanthin has also been shown to reduce the risk of HIV infection by inducing inhibition on the cell surface.
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