Dehydroepiandrosterone (DHEA) is a multi-functional steroid that has been implicated in a broad range of biological effects in humans and other mammals. Together with its sulfate ester (DHEA-S), it is the most abundant steroid in humans. DHEA is produced by adrenal glands, but also sythesized de novo in the brain. It acts on the androgen receptor both directly and through its metabolites, which include androstenediol and androstendione, which can undergo further conversion to produce the androgen testosterone and the estrogens estrone and estradiol. DHEA is also a potent sigma-1 agonist. It is considered a neurosteroid.
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